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Like other antiarrhythmic drugs of this class, amiodarone works primarily by blocking potassium rectifier currents that are responsible for the repolarization of the heart during phase 3 of the cardiac action potential. Click to see full answer Amiodarone and Thyroid Function Amiodarone40 inhibits the peripheral conversion of T4 to T3, leading to a 25% fall in T3 concentration and a slight rise in T4 and thyrotropin concentrations. Because of its high iodine content, amiodarone can also inhibit the synthesis and secretion of T3 and T4. Amiodarone is a potent inhibitor of the hepatic and renal metabolism of several drugs (Table 3). 4, 21 – 25 Amiodarone inhibits metabolism through several cytochrome P450 pathways, including CYP Amiodarone (Cordarone) is a commonly prescribed medication for the management of both atrial and ventricular arrhythmias. Unfortunately, when amiodarone is given to a euthyroid (normal thyroid function) patient , the normal physiologic process for the formation of the thyroid hormones, thyroxine (T4) and 3,5,3'-triiodothyronine (T3), can be adversely affected.

av H Appelqvist · 2012 · Citerat av 66 — desipramine, imipramine and amiodarone, used to treat e.g., depression and arrhythmias [16], [17].

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The mechanism is related to the high iodine concentration associated with each dose of amiodarone.

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It is used to help keep the heart beating normally in people with life-threatening heart rhythm disorders of the ventricles (the lower chambers of the heart that allow blood to flow out of the heart). Amiodarone is used to treat ventricular tachycardia or ventricular fibrillation. Mechanism of Action Amiodarone is a primarily a class III antiarrhythmic. Like other antiarrhythmic drugs of this class, amiodarone works primarily by blocking potassium rectifier currents that are responsible for the repolarization of the heart during phase 3 of the cardiac action potential. Mechanism: The mechanism of action of amiodarone is complex.